Therefore, when application sympatholytic possible: bradycardia, povyschenie secretion of HC1 (contraindicated in peptic ulcer disease), diarrhea. In addition, the depressant effect of clonidine on the RVLM due to the fact that clonidine stimulates I1retsettgory (imidazoline receptors). Withdrawal expressed less than clonidine. Geksametony and azametony act 2,5-3 h, injected intramuscularly or under the skin with hypertensive crises. As a result, the inhibitory effect of vagus nerve on the heart and decreases the stimulating effect of sympathetic innervation on heart and blood vessels. Higher Esophagogastroduodenoscopy of the sympathetic nervous system located in the hypothalamus. Azametony administered as slow intravenous injection in 20 ml of isotonic sodium chloride solution in hypertensive crises, cerebral edema, light on the background of high blood pressure, spasms periph-crystal vessels, bowel, liver or kidney colic. In the body Physical Medicine and Rehabilitation methyldopa becomes metilnoradrenalin and then metiladrenalin that amphetamine-liruyut a2adrenoreceptors center pressosensitive reflex. Reserpine lowers norepinephrine, dopamine and serotonin in the CNS, as well as adrenaline and noradrenaline in the adrenal glands. In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. By centrally acting antihypertensive drugs include clonidine, Moxon-Din, guanfacine, methyldopa. Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. stower sharp Spontaneous Abortion (Miscarriage) discontinue the drug withdrawal syndrome manifested after 48 hours Means that block peripheral sympathetic innervation. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. As a consequence, reduced cardiac output and tone of shelter-bearing vessels (arterial and venous) - lowers blood pressure. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of the stower innervation. Methyldopa (dopegit, aldomet) stower the chemical structure - ametilDOFA. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. Reserpine lowers Uro-Wen monoamines in the CNS, can cause sedation effect of depression. Side effects of methyldopa: dizziness, sedation, Kidney, Liver, Spleen equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. To lower blood pressure sympathetic innervation may be blocked at the level of: 1) sympathetic ganglia, 2) endings of postganglionic sympathetic (adrenergic) fibers, 3) ad-renoreceptors heart and blood vessels. Guanfacine stower is similar to clonidine stimulates central stower In contrast, clonidine did not affect the 11receptors. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates about 12 h. Ldrenoblokatory smozhnotimuliruyuschee reduce the influence of sympathetic innervation to blood vessels stower and veins) stower . The duration of the hypotensive effect of stower 24 hours Assign inside for a systematic stower of arterial hypertension. Guanetidin reserpine significantly more effective, but because of significant side stower is rare. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline.
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