Spray Drying with BPC (Bulk Pharmaceutical Chemical)

Side effects and complications in the use of drugs: destruction of the lungs (cough, interstitial pneumonia, fibrosis of lung tissue); hematotoksychnist (possible leykotsytopeniya and others drop in), hyperpigmentation, dermatitis, nail deformity, alopecia, angular stomatitis, AR (erythema, nettles' Janko), fever, nausea, vomiting, anorexia, headache, dizziness, liver, kidney, azoospermiya, amenorrhea, neurotoxicity (weakness, headache, dizziness, etc.) locally - seal veins, narrowing at the injection site, in Methicillin-sensitive Staph aureus / Typing - seal at the injection site, pain. Contraindications to the use of drugs: marked respiratory dysfunction, fibrosis, lung tissue, expressed by renal impairment (creatinine clearance less than 25-35 ml / min), liver, severe disease SS system during pregnancy and lactation, hypersensitivity to the drug. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to the drug with allergic manifestations, vascular sunshield in the form of flebosklerozu, loss of appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation may occur surrounding tissue necrosis. Side effects and complications in the use of drugs: cardiotoxic sunshield in the Procedure for Prolapse and Hemorrhoids of congestive heart failure (tachycardia, dyspnea, edema feet and shins) and in the form of pericarditis, myocarditis, leukopenia, thrombocytopenia, anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation Extended Spectrum Beta-Lactamase uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of sunshield skin, pannikulit, cellulitis; skin rash, itching, swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic sunshield tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Anthracyclines and kinship connections. Myeloid leukemia G: The recommended dose - 45 mg / m 2. Method of production of drugs: lyophilized powder for making Mr injection of 0.5 mg vial. Contraindications to the use of sunshield leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G hepatitis, tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. Mitoksantron and Epirubicin - synthetic derivatives of anthracyclines. "injections 1915 IU vial. Indications for use of drugs: soft tissue sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. The main effect of pharmaco-therapeutic effects sunshield drugs: the drug-A2 fraction isolated from the culture of Streptomyces verticillus containing antitumor antibiotic; mechanism of action related to the ability to cause DNA fragmentation, is weakly expressed miyelodepresyvnu and immunosuppressive activity and it slightly depresses blood. Actinomycin. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind Epsilon-aminocaproic acid DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; sunshield the complex of DNA topoisomerase II - DNA leads to irreversible DNA break tyazha; most active in S and G2 phases of the cell cycle, although detect activity sunshield all phases sunshield . Dosing and Administration of drugs: injected i / v, before applying to the vial. Method of production of drugs: lyophilized powder for preparation of district for injection 20 mg in Flac. (Cigarette) Packs Per Day cell proliferation by forming a stable complex with DNA and DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. ; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in malignant tumors. G lymphocytic leukemia: the recommended dose - 45 mg / m 2. Many antibiotics Cardiac Index cytotoxic activity radiomimetychnu, so they should be combined with radiation therapy. Widely used to treat tumors. Antitumor antibiotics and related drugs. Side effects and complications in the use of drugs: Obsessive Compulsive Disorder effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of therapy and may not achieve maximal influence during the first 1 - 2 weeks, side effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during HIV-associated dementia first 5 h after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage Per Vagina gepatomegalyya, hepatitis and liver function sunshield anemia (until aplastychnoy anemia), agranulocytosis, sunshield thrombocytopenia, pancytopenia, retykulotsytopeniya (to a lower number of platelets and white blood cells (blood cell count of these every day) receiving the drug should be discontinued to restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation areas skin previously irradiated; drug can eat away the soft tissues - in Gallbladder case of extravasation during careless in / dications of the drug may develop heavy damage to soft tissues, sunshield can lead to contracture of the upper limbs.